Suppose the only study on age-related mortality shows that people older than 30 are 1.2x more likely to die in a given year than people younger than 30, but does not give any other information. Ive since backed off of it a bit, maybe not because I think its wrong but because theres possibly a larger and more interesting explanation for what we see, which is that both the collection of deficits that go with low-functioning ASD and the neural efficiencies that go with high IQ are both at least partially caused by a twitchier immune system, which in turn is creating a different profile of synaptic pruning as the brain develops. One way of resolving the autism-intelligence paradox is to say that familial genes for autism increase IQ, but de novo mutations and environmental insults decrease IQ. Doing some [fundamental] discovery is harder and harder. As for genetics, well, my IQ is ~135, and my wifes is right there with me (~125). About impulse control, there are two strategies being selected for here, one featuring low impulse control(the classic idiocracy strategy) and another (the religious socially conservative strategy) featuring high impulse control: https://www.sciencedirect.com/science/article/pii/S2352250X18300976. Normality is just too vague to be quantifiable. However, history doesnt always predict the future. There is also some link to male sex, I do believe that there are higher levels of males with low intelligence autism. Just look at Kanye West, for example. You could compare those estimates for IQ to those for height. control children (though see the discussion here) for some debate over how seriously to take this; I am less sure this is accurate than most of the other statistics mentioned here. Or rather, that the concept of Asperger autism is more related to giftedness, and not to autism. We cant do much about the genetic or random developmental stuff, but we can make sure most of the things that have stunted peoples intelligence over time go away. Research suggests that there is an ongoing reversed Flynn effect, i.e. If this is good, then by definition, more at the margin will be better. Reading about this seems a little bit strange at first, but I must say, I teach in the mathematics department of a university, and I observe this everyday in my best students. I am not, but we both initially bonded over (I dont know a way to put this delicately or more exactly) being objectively very smart people that dont perform intelligence very well, albeit different ways. German Shepherds, Huskies). What are the percentages of children who fall in each group? Id figured out myself how to do that, but tried to hide that I knew how because I thought I wasnt supposed to know yet. As an example of the latter there was a time when I was in math class when wed started learning about simple equations with variables (4n + 2 = 3n + 5 or whatever) but we hadnt yet learned about adding things to both sides (I think we were just supposed to guess and check). The genes that control the development of that definitely dont do so in a linear or easily explainable way. Increased parental age correlates with autism risk, AIUI. Go up a level and you can mash a bunch of sequential notes on a piano with one left out of the middle and they can tell you the highest note, lowest note, and the one you left out. This is interesting to me, since I am on a career path to become a high end career civil servant, GS-12 at 25 years old for those that know what that means, and I am anything but normal. The difference between high and low functioning autistic children is significant. Most cases of autism involve all three of these factors; that is, your overall autisticness is a combination of your familial genes, mutations, and environmental risk factors. If autism is a result of piling up too many high-IQ alleles, then youd expect to see far more of it in the children of scientists, lawyers, engineers, doctors, mathematicians, etc., than in the children of janitors, file clerks, policemen, nurses, etc. Autistic people have weird developmental trajectories. Maybe this is old news to most people, so I wont belabor that point any more, but what about the link between high IQ and a different immune function? First, the studies. I think its possible that some relatively simple model will be found to explain this relationship, but I also think its possible that the mechanics of intelligence are simply complex enough that the explanation is something inaccessible with our current level of understanding. children who previously had normal or even remarkable verbal abilities for their age suddenly losing words. She pointed out that there are a couple widely-used kinds of IQ test. The normies were not spergs running emulations, theyd have the same confused look whenever we sperged-out about something that we had when they talked about sportsball. Why on Earth one would assume that the effect of genes that contribute to IQ should be linearly additive and increasing to ad infinitum? Higher IQ people have lower infant mortality rates than lower IQ people. Im very open to people arguing the contrary, but I must say, in 8 years of doing abstract mathematics, I never met an Asperger-like person where giftedness did not seem to be part of the equation. I think, everywhere. Terrifyingly competent and motivated, shockingly good with people, and with few visible mental issues. Non-genetic factors. I am getting a vision of the future. So in that sense, maybe its just a phrasing problem. Rare de novo mutations, ie the autistic child gets a new mutation that their non-autistic parent doesnt have. the genetic load would be due to bad luck in parent mixing (recessive-recessive pairs) and parent age. Maybe even only a small fraction of potential arrangements are just right to produce ever-increasing levels of some capability in the phenotype. If anything, theres a slight positive correlation between the two. I think this is connected to gifted people tend to be good at finding creative solutions to things rather than the most obvious ones, which in the case of weird walking or talking styles can look like autistic behavior. My son was measured using the full Weschler and most of his scores were 96-99th percentile (thats VERY high). Why do you think they arent sperging out about sportsball? Awareness of it? We start with a presentation of a summary of the article, and then discuss in a friendly atmosphere. She has an article on her website here: https://hennyk.com/autism-and-perfect-pitch/ and a book: https://hennyk.com/book-perfect-pitch-in-the-key-of-autism/. I was thinking of Sickle Cell Anemia, where if you get the gene from one parent you are immune to malaria, while if you get from both, your blood cant carry enough oxygen. Also, if we do get to a bold new future of hyper-intelligent unilaterism, would the hyper-intelligent even want to sign up for it? This should be surprising; why would too many intelligence-promoting variants cause a syndrome marked by low intelligence? If the g factor and IQ gains from the Flynn Effect are negatively correlated, then does that mean that IQ tests are gradually being more and more poorly designed over time? If you get the volume knob too close to the feedback point, the sound will start to behave strangely it will ring weirdly in a way its never done before. The familial genes mentioned above: common genes that increase IQ and that evolution positively selects for. But there is a critical point in the system, the feedback point, after which more isnt just too much of a good thing the behavior of the system changes qualitatively and the whole thing breaks down. Well, I think its certainly a reasonable possibility, which in my experience appears to be true, that beyond a certain point, intelligence either directly causes weirdness or is reliant upon it as a foundation. 2015, p. 81). It is very, very smart, but nobody dares reproduce naturally anymore, not because the equipment doesnt work, but because genetic engineering means everyone pushed every single one of these levers to the setting marked beyond this point, there be dragons, and at least half their kids would die or come out completely non-functional if they tried it. Is it the reverse of that? Because theres a correlation between IQ and race, overdiagnosing the children of a higher IQ group with autism (or underdiagnosing the children of a lower IQ group with autism) results in a correlation between IQ and autism which is actually just caused by racial bias in diagnosis rates. They come from random plants or shiny rocks or stuff Alexander Shulgin invented to get high. Interestingly, this one addresses the P>V, and V>P subtypes and suggests: children with ASD did not show the commonly understood characteristic profile on the WISC either in terms of PIQ-VIQ discrepancy or in terms of peak skills on particular WISC subtests. What if autism does two things: it has a tendency to break enough normal processes to make someone rather nonfunctional, and it also has tendencies to increase perceptual ability and intelligence. The existence of a well-defined subset of low IQ people whose relatives have higher-than-predicted IQs is a surprising finding that cuts through the measurement difficulties and suggests that this is a real phenomenon. This has nothing to do with the OP, but I will definitely comment on your wrestling example, as a wrestler. Theres a question if you want to go really far out, outside the modern human range, and you might get unforeseen side effects. High-functioning autism looks more like the same polygenetic soup one finds with other complex personality characteristics like intelligence or Big Five character traits. I still sometimes feel bad about whether that ended up slightly ruining some sort of investigation into which methods of teaching spelling were better or something like that. From a certain perspective, it merges with normal. In sum, these findings suggest that neurodevelopmental social impairment exists in varied forms with varied etiologies and varied pathophysiologies, but the ASD diagnostic criteria do not identify a valid entity, Link to the entire piece https://link.springer.com/content/pdf/10.1007/s40489-016-0085-x.pdf. Some of this effect is because autism is caused both by normal genes and by de novo mutations and environmental insults, and the de novo mutations and environmental insults definitely decrease intelligence. Even when adults with autism live outside the family, their families especially their mothers have extensive contact and involvement in their care. Aspergers was definitionally distinguished from autism due to a lack of the cognitive deficits associated with that condition, but in 2013, the DSM-5 folded it into autism spectrum disorders, so this could make it difficult to analyse the genes of high function autistics if that was the mistake I believe it was. Altruisto is a browser extension so that when you shop online, a portion of the money you pay goes to effective charities (no extra cost to you). IQb + low genetic load : extremely high intelligence, slight or undetectable autistic tendencies, strongly tenchnically inclined For one, its multiple different kinds of mental tasks whose scores are then combined to get an IQ score. Several studies have shown a genetic link between autism and intelligence; genes that contribute to autism risk also contribute to high IQ. Lazy googling yields claims around 80% narrow-sense (additive) heritability for height which is comparable to the total heritability of IQ. I am not saying they have the full disorder (and no its not a partisan snipe, except to the extent that being very skeptical of the US bureaucratic class is partisan). He has the making of a superb engineer. Intelligence and social aptitude dont seem to be positively correlated, at least not very strongly, but theyre definitely not negatively correlated. These are the people that make the Turing test invalid, youd think they were the chatbot. The Charman et al study finds a correlation between autism and low IQ, by starting with a sample of autistic people and looking at their IQs. (So I dont understand why confidence goes down so much for point 5 in the conclusion of the original post, from 80 to 25 percent.). Has anyone here actually met a highly intelligent person who is genuinely normal? Energy/perseverance/drive and other harder to measure factors. Low-functioning autism has all kinds of genetic linkages to all kinds of different genetic syndromes that cause brain damage, damage that often extends beyond autistic symptoms. There are maybe as many as 1000 of them in the Western world, and none of them would want to ever hang out with us because they are smart enough to know that their time would be better spent managing their billion-dollar corporations and/or governments. To test this, you could see if higher IQ autistic people tend to have more or fewer of these genes correlated with high intelligence, compared to low IQ autistic people. I am known as a word smith (and its an important part of my career, but Im not in journalism). @Cliff All this is a purely hypothetical thought-experiment, of course. In particular, the excess of alleles associated with higher intelligence and educational attainment was only observed in the higher functioning categories (particularly Aspergers syndrome and individuals without comorbid intellectual disability) and not in the other/unspecified PDD and intellectual disability categories. Do a lot of super smart people play the game? (Then also add to that the fact that people making a big deal out of Wow you can do this thing! can be super unpleasant). Youre starting with the premise intelligence is incompatible with normality and then reflexively dismissing all evidence to the contrary with theyre not really normal, theyre just pretending. Which is 1.) Thus, any sample of fathers is likely to overestimate the average IQ of fathers on average because fathers are around to be measured (arent in jail, arent dead, didnt just take off) have higher average IQ than those who who arent around to be measured. The reality is that weight training only increases strength in the motion of the lifts that you do. As an AI researcher, this actually seems pretty intuitive for me. Its also a chapter of The 10,000 Year Explosion. This gene developed in Africa, and can be seen as a fundamental reason for the transatlantic slave trade. Highly intelligent people are likely to have different interests, read and talk about different things, than average peopledoes that make them not normal? Beware Simpsons Paradox. Its not because simply being small or being large or having a flat face are inherently unhealthy traits; there are other species that are much smaller than Yorkies, much larger than Great Danes, and have flatter faces than Pugs, without suffering any problems as a result. They find that even autistic people without de novo mutations have lower-than-average IQ. focus on the denotations of words, not the emotional or social connotations. Potential confounder: having a low-functioning autistic child is highly stressful and often unpleasant. Only 3% of autistic people were found to have IQs above 115, even though 15% of the population should be at this level. Tongue in cheek (Swift Modest Proposal) style interventions given this model are: You tell them that the study that tried to address that question suggests that they are between one point one and one point two times as likely; in other words, at least 83-90% of their chance to die in any given year is baseline. He is the most Civil Servicy person around. The ICD-11, which was adopted this year and will be implemented globally by 2022, instead calls it autism spectrum disorder without disorder of intellectual development and with mild or no impairment of functional language. Proponents of the change hope to reduce stereotypes. FWIW, I know a few bona-fide genius-level people; on the order of Ph.D. Over the vast majority of the range of the main volume knob on the mixer (assuming the system is set up reasonably), more will be better. Non-autistic geniuses are compatible with the proposed hyperparameter model, unless Im missing something. Slate Star Codex (SSC) was a blog focused on science, medicine (especially within psychiatry ), philosophy, politics, and futurism. [Thanks to Marco DG for proofreading and offering suggestions]. High IQs appear to be selected for, as does ASD; while the the survival advantage of the first is obvious, the second is a really high cost to pay from a fitness standpoint, and Im skeptical that the IQ on its own would be worth it as a survival advantage. Perhaps the mechanisms for high IQ autism and low IQ autism are different. I suspect that this is the case. The lectins in wheat interfere with leptin receptors, making people leptin resistant and therefore obese. People with average or above average intelligence and autism are much, much less likely to be diagnosed, because one contributing cause of a diagnosis is seeing a psychiatrist, which is much more likely for people who are having trouble in classes. Seriously, what sort of advice do you expect? Regarding Narcissim, the first website I pulled up had these as the first 3 symptoms: * Have an exaggerated sense of self-importance One big category would be selection bias due to diagnosis bias. We have limited time to dedicate to know these genius, and a big part of it is dedicated to old ones. Its not difficult to guess what someones response would be to many chit-chat topics. And of course theres always survivor bias. And also reproducing younger (banking frozen eggs and/or sperm early for the IVF). 6 6 6 6 6 marries 6 6 6 6 6, decent chance of getting a 9 9 8 7 9 stone cold genius. Ah, that would explain the discrepancy. If Im not, that suggests one of three things: [1] I assume most such genes do something way more complicated and hard to measure, but head circumference makes a nice example trait. As long as I kept useful inventions flowing out of my lab, I think hed pay me well and insulate me from social criticism. Overall scores could continue to rise due to the Flynn effect even as intelligence is being selected against on a genetic level, which is what the evidence is suggesting. Genes encode changes to these hyperparameters. The best-studied are probably obstetric complications, eg a baby gets stuck in the birth canal and cant breathe for a long time. Not just running an emulation of normal to deal with other people? In the graph of relatives, are autists typically on the border or inside of high-IQ regions? Thats probably how he got to that level. A lot of the super smart people I know also seem super interesting either being very funny, uniquely talented, or engaging. So, part of people's problem is with the origins of ABA. My parents were optometrists. https://slatestarcodex.com/2019/05/07/5-httlpr-a-pointed-review/, https://sci-hub.tw/10.1176/appi.ajp.2018.18070881, Arizone State University Autism symptoms reduced nearly 50% two years after fecal transplant, The Economist More evidence that autism is linked to gut bacteria, Maybe Your Zoloft Stopped Working Because A Liver Fluke Tried To Turn Your Nth-Great-Grandmother Into A Zombie, https://link.springer.com/content/pdf/10.1007/s40489-016-0085-x.pdf, http://cepuk.org/unrecognised-facts/diagnostic-system-lacks-validity/, https://medicine.uiowa.edu/psychiatry/content/ui-research-suggests-huntingtons-disease-gene-also-vital-human-development-and-intelligence, https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2749054, https://bmjopen.bmj.com/content/9/8/e029040.full. Im somewhere on the autism spectrum and have high levels of anxiety. (Apologies for a machine metaphor that is certainly misleading, but better than anything else than I can think of.). I was getting my disorders mixed up, yes, but this is the one I was thinking of. was too big to go through the birth canal! A lot of dog breeds, particularly those that are very small (like Teacup Yorkies), very large (like Great Danes), or otherwise very different from the default canine somatoform (like Pugs), tend to suffer from health problems at a vastly higher rate than mutts or more natural breeds (e.g. (1) genes that promote autism are correlated with IQ and ), but the non-additive portion is of roughly comparable size. But if you pile on enough of the genes that increase IQ by increasing your head circumference, you will get a kid with such a huge head that his neck wont support it and his heart and lungs cant keep his giant brain in oxygenated blood, and hell die as a baby. Combining information from a wide variety of studies, Gaugler et al estimate that about 52% of autism risk is attributable to ordinary familial genes, 3% to rare de novo mutations, 4% to complicated non-additive genetic interaction effects, and 41% unaccounted, which may be non-genetic factors or genetic factors we dont understand and cant measure. No need for (extremely valid) concerns about whether IQ tests accurately measure (normal/low) functioning autistics, e.g. So I gave that fact to save others the effort to dig for it, while trying to give a subtle hint to you that it is better to include the finding. These things are incredibly synergistic in some people, allowing them to do exceptional things, we notice thisso we start to associate them with one anotherbut the presence of one means absolutely nothing about the presence of any others in general, and you need to scale up all or at least many of them to get any good returnsworse, some factors may not need to go any higher, otherwise theyll just be a hindrance. However, I wouldnt be surprised if a statistically high proportion of people here are autistic or have autistic family members. The genes and developmental stuff is one part, an enriching environment in childhood is another, and the physical requirements (adequate nutrition and good health and few toxins present during critical parts of brain development in childhood, continued good health in adulthood). I then play out both parts of the conversation from memory as their mouth gapes open.). Every autism case is caused by some combination of these three factors, and the more it is caused by normal genes, the more intelligence is likely to be preserved (~100% confidence), 4. Metaculus is a platform for generating crowd-sourced predictions about the future, especially science and technology. I spent a lot of time reading about giftedness (having a IQ > 130) in the last few months, specifically educating gifted kids and teenagers, and I found out quite some things about how giftedness can interact with social ability: It turns out that giftedness can be quite a burden for children and teenagers, as not many of their peers can relate to them and vice versa. Karpinksi et al. When I was a music major in college it was the research interest of one of my professors and he put the students with perfect pitch through a couple of tests like this in class. Being a carrier for cystic fibrosis may be protective against cholera. Anyway, if the data were there, I would suggest an alternate explanation that a significant portion of gender dysphoria is socially mediated, and the autistic are isolated from the social phenomenon. Within our filter bubble, people have similar levels of status, so they can be smart but not charismatic or charismatic but not smart. Its not like theyll answer anybody. I work with with a lot of very smart people, and have throughout my career. Shes unable to work in a normal public school classroom, but luckily we have a charter school that specializes in children with autism that has worked well for her. Precision of it? I would say half of the up and coming civil leaders have hints of being abnormal. But that wouldnt be the way to bet, IMO. Right, genes are NOT good or bad. g_i = 1 if the parameter is present, g_i = 0 if not. Below are two lists taken from an autism checklist and a reactive attachment disorder list. however, ASD without these two confounders shows no correlation with IQ. And so humans recently had/still are having a massive selection for genes that require lower thresholds for immune responses, and genes that outsource some of the immune de-escalation responsibilities to gut microbes and parasites, etc in order to get a faster jump have proliferated to the point where a lot of these are normal now; this is the hygiene hypothesis or old friends hypothesis and the best outline of I can offer for it is the book An Epidemic of Absence by Moises Velazquez-Manoff. It was my first thought, too admittedly followed by the second thought wait, no, theyll have thought of that one ages ago. how could they recruit in such a way as to get a representative sample? Well, there is a point, but it takes a long time to grasp it, at which point you are significantly behind people who went along with them without questioning them. And then theres Jacob Collier, who can detect, and accurately sing, the difference between an A at 440Hz and at 432Hz, and that allows him to do stuff like this (https://www.youtube.com/watch?v=mPZn4x3uOac) where he sings a 10-part harmonisation of In the Bleak Midwinter in which hes gradually shifting the key-centre upwards throughout, and then for the last verse he performs a 4-chord pivot to a key halfway between G and G# on the scale hes in at the time, by taking advantage of slight mis-definition in the equal-tempered approximations to those pivot chords that allows him to quickly shift to an entirely out-of-tune system (if you switched directly, it would just sound like trash) in just four chords without it sounding odd. Additionally, look at the lives of geniuses throughout American history. Moreover, if your family isnt too bright, you might not even recognize that theres something funny about your latest kid. Either way, I dont think you can have one without the other above a certain level. Why on Earth people take a decomposition of intelligence quotient such as the v-p-r, while itself fairly reasonable sounding but also very broad, and take seriously attempts to shoehorn that as the biological mechanism behind a very handwavy metaphor-like explanation such as tower and foundation?It is blatantly obvious that v-p-r is a very crude model that should not make sense. Etc. But the basic eugenics of moving intelligence higher at the margin through differential fertility, or the soon-to-be possible embryo selection for intelligence, this is not an argument against that. 2. Dr. Laura Baur is a psychiatrist with interests in literature review, reproductive psychiatry, and relational psychotherapy; see her website for more. There was a Conversations With Tyler podcast with Michelle Dawson (link here including transcript) where this was discussed. Why? A bit of motivation before asking a question: my boss has a daughter. This pattern is not uncommon (my son followed this trajectory), and is partly responsible for the even less uncommon belief that vaccines cause autism, because the regression coincides with vaccination. This is the only study I know that has actually measured autism rates in the general public. In a situation where being outcast from the tribe means that the tribe is going to die instead of the outcast, then the tribe had better learn to put up or shut up. The two may or may not be correlated (Im honestly not sure), but theyre not the same thing. My wifes father (an engineer) is likely autistic. There are huge practical and financial incentives within our system to diagnose all of these sets of kids with some kind of medicalized disorder, regardless of whether any underlying physical mechanism is understood or present (and sometimes it is, but many different developmental issues can lead you down each of these roads). But for me the key point is that high-intelligence fathers show a trend (albeit not significant in this study) to be more likely than average to have children with autism and intellectual disability. More generally, to relate to those people around you who are also bright. (2) genes that promote autism are being selected for Id say his IQ is similar to or higher than mine (around 135.). Being a deadbeat or loser, or being perceived as same, may be a result, not a cause, of the specifically low-functioning types. Check out their free anti-anxiety guide here. Theres probably not anyone working in math right now who is any smarter than Gauss was. A link between Tay-Sachs gene and intelligence. when we did a comprehensive neuropsych his IQ came back above average (range 115-125ish depending on how you weight scales) which seems about right. Substack is a blogging site that helps writers earn money and readers discover articles they'll like. accident route 1 princeton, nj today, ford seat cover replacement,

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